Capivasertib, a breast cancer treatment targeting a specific gene abnormality, has demonstrated significant clinical efficacy. Like many other medications, capivasertib use may be accompanied by a range of side effects.
Most Common Adverse Reactions (Incidence ≥20%):
Diarrhea, skin reactions, random hyperglycemia, lymphopenia, decreased hemoglobin, increased fasting blood glucose, nausea, fatigue, leukopenia, increased triglycerides, neutropenia, increased creatinine, vomiting, stomatitis.
Cardiovascular System: Less common: Acute myocardial infarction.
Skin System
Very Common: Adverse Skin Reactions
Adverse skin reactions include butterfly rash, dermatitis, generalized exfoliative dermatitis, toxic rash, dry skin, eczema, erythema multiforme, hand dermatitis, palmoplantar erythema sensory disturbance syndrome, pruritus, rash, erythematous rash, maculopapular rash, papular rash, hyperpigmentation, fissuring, skin reactions, skin ulcers, urticaria, purpura, erythema, and drug eruption.
Gastrointestinal System
Very Common: Diarrhea, nausea, stomatitis, vomiting;
Frequency Not Reported: Indigestion.
Hematologic System
Very Common: Lymphopenia, decreased hemoglobin, leukopenia, neutropenia, thrombocytopenia, anemia.
Hepatic System
Very Common: Elevated alanine aminotransferase.
Anaphylactic Reactions
Uncommon: Anaphylactic reactions, including anaphylactic shock.
Metabolic System
Very common: Random hyperglycemia/hyperglycemia, elevated fasting blood glucose, elevated triglycerides, corrected calcium deficiency, decreased appetite, decreased potassium;
Common: Elevated glycated hemoglobin;
Uncommon: Diabetic ketoacidosis.
Hyperglycemia includes elevated blood glucose, elevated glycated hemoglobin, impaired glucose tolerance, diabetes, hyperglycemia.
Nervous System
Very common: Headache;
Common: Gustatory disturbance;
Uncommon: Cerebral hemorrhage.
Other
Very common: Fatigue;
Common: Mucosal inflammation;
Uncommon: Sepsis;
Fever not reported.
Renal System
Very common: Elevated creatinine, urinary tract infection, kidney injury;
Kidney injury includes acute kidney injury, kidney failure, impaired kidney function, decreased glomerular filtration rate, elevated creatinine, proteinuria.
Respiratory System
Uncommon: Aspiration pneumonia
Pneumonia not reported.
